MAP Platform Technology

Microporous Annealed Particle (MAP) gel, invented by Dr. Griffin, is a synthetic injectable material that forms an open pore scaffold in situ, promoting extensive tissue ingrowth and accelerated wound closure. MAP gel is composed of polyethylene glycol (PEG) microspheres that form a solid, open pore scaffold, resulting in a minimal immune response. MAP gel has shown tissue integration due to interconnected microporosity, which can have tunable physical and degradation properties.

Our research focuses on controlling MAP surface chemistry, porosity, and delivery in order to promote tissue integration and regeneration.

 

Our Projects

MAP optimization

Microporous annealed particle scaffolds consist of a slurry of hydrogel microspheres that undergo annealing to form a solid scaffold. We are interested in further optimizing this technology for a variety of clinical uses by exploring new chemistries.

Publications:

Selected and Improved Photoannealing of Microporous Annealed Particle (MAP) Scaffolds

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Heterogeneous Scaffolds

Microporous annealed particle hydrogels uniquely allow for the development of heterogenous scaffolds by mixing particle types. We have specifically explored MAP gel with heparin islands to interact with endogenous signals and form spontaneous microgradients to guide tissue ingrowth.

Publications: 

Spatially Heterogeneous Epidermal Growth Factor Release from Microporous Annealed Particle (MAP) Hydrogel for Improved Wound Closure

Heparin Microislands in Microporous Annealed Particle Scaffold for Enhanced Diabetic Wound Healing Outcomes (preprint)

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